Unseen Upside S4:EP5 Unlocking the Dark Genome for Lupus & Other Autoimmune Diseases

Autoimmune diseases like lupus impact over 5 million patients globally, but treatment options remain limited. Now, decoding the once mysterious "dark genome" could bring new therapies. Over 90% of our DNA was once considered "junk"—but we’ve learned this dark matter regulates gene expression and human disease. This episode takes you to the pioneers who are unlocking the dark genome's potential to correct root causes of complex conditions like lupus. We'll chat with those illuminating this uncharted territory and developing novel approaches, including Dr. Rosana Kapeller (Rome Therapeutics); Steve Kafka (Section 32); and Katherine Cavanagh (Cambridge Associates).

Listen to episode five here.